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Talzenna , from Pfizer, was approved for the treatment of people with BRCA-mutated breast cancer that does not express HER2 The FDA approved a companion diagnostic test, called BRACAnalysis CDx, to help select eligible patients The drug is approved for those with either locally advanced breast cancer or cancer that has spread elsewhere in the body, a process known as metastasis anywhereweroam com places-to-visit-in-the-uk TALZENNA is a prescription medicine used alone to treat adults with a certain type of breast cancer (gBRCA-mutated, HER2-) that has spread to other parts of the body (locally advanced or metastatic ) Your healthcare provider will perform a test to make sure that TALZENNA is right for you It is not known if TALZENNA is safe and efective in children Women with stage IV breast cancer are most often treated with hormone therapy, chemotherapy, targeted therapy, immunotherapy, or some combination of these Surgery or radiation might be used to help prevent or treat symptoms See risks and benefits of TALZENNA ® (talazoparib), a once-daily oral PARP inhibitor for treating gBRCAm HER2- locally advanced or metastatic breast cancer What is targeted therapy for breast cancer ? Targeted therapy for breast cancer refers to treatments or drugs that specifically target cancer cells while leaving normal cells mostly unscathed To develop a new targeted therapy for breast cancer , researchers must first uncover the factors that drive normal cells to become breast cancer cells For patients seeking more targeted therapies, Talzenna (talazoparib) offers a promising option In this article, we’ll explore how Talzenna works in the treatment of metastatic breast cancer , its effectiveness, and the role of leading treatment centers like UCI Health in offering this cutting-edge therapy Top UK holiday destinations to visit at least once in your life These are the best UK staycation ideas for a short break at home5 days ago · Pfizer’s PARP inhibitor Talzenna has become the first targeted treatment for HER2-negative locally advanced or metastatic breast cancer with BRCA1 2 mutations to be recommended by NICE for --- countryliving com uk travel-ideas staycation-uk uk-holiday-destinationsThe absolute best places to visit in the UK including the top scenic attractions and most interesting cities, plus what to do and a map Approval was based on EMBRACA (NCT01945775), an open‑label trial randomizing 431 patients (2:1) with gBRCAm HER2‑negative locally advanced or metastatic breast cancer to receive talazoparib (1 Talzenna (chemical name: talazoparib) is used to treat locally advanced or metastatic HER2-negative breast cancer with a BRCA1 or BRCA2 mutation Feb 20, 2025 · PARP inhibitors and metastatic breast cancer treatment Olaparib and talazoparib are used to treat HER2-negative metastatic breast cancer in people who have a BRCA1 and BRCA2 (BRCA1 2) inherited gene mutation and have been treated with chemotherapy at least once in the past (including chemotherapy for early breast cancer )

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